医学部坐倚珞珈山,环绕东湖水,绿树成荫,花香流溢。学部源于1943年成立的湖北省省立医学院,现在是武汉大学六大学部之一。 学部含基础医学院、第一临床学院、第二临床学院、口腔医学院、药学院、健康学院、职业技术学院...

地址: 湖北省武汉市武昌区东湖路115号
电话:027-68759376
中国科学院院士: 邓子新舒红兵
国家级教学名师: 樊明文边专
国家杰出青年基金获得者: 邓子新舒红兵郭德银章晓联万芪李红良
千人计划入选: 霍文哲张发明、于学杰
青年千人计划入选: 陈实蒋卫钟波张好建、陈强、罗孟成、邓迎峰
百千万人才工程选者: 舒红兵、黄从新章晓联 
长江学者: 董晨舒红兵李红良
万人计划: 领军人才:舒红兵唐其柱李红良   青年拔尖人才: 刘天罡 、

王连荣王培刚          
     
教育部新世纪优秀人才: 何小华 于红刚 李雁郑芳、胡锦跃、黄鹤
临床试验中心 湖北省腔镜泌尿外科医学临床研究中心 湖北省痴呆与认知障碍医学临床研究中心 湖北省肠病医学临床研究中心 湖北省肿瘤医学临床研究中心 肿瘤生物学行为湖北省重点实验室 肠病湖北省重点实验室 移植医学技术湖北省重点实验室 武汉市泌尿男生殖系肿瘤临床医学研究中心
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金秋十月医学部多批海内外校友返... 河南校友会医学分会成立 国庆节期间多届海内外校友返校聚会 2016年全校校友及筹资工作座谈会... 海外杰出校友助力医学部发展 武汉大学大纽约地区校友会生化医... 65级老学长回母校团聚 医学部迎接多批次校友返校 武汉大学医学部海外校友会
医学部两名校友当选第十九届中央... 医学部79级校友李建明当选国家体... 校友王艳玲当选湖北省委常委、宣... 医学部79级校友李建明当选国家体... 92级校友许永涛荣获全国五一劳动... 校友孟祥金入选美国科学院院士 向1947级校友致敬 92级校友许永涛荣获全国五一劳动... 武汉大学杰出校友童朝晖
武汉大学医学部1986级合影 武汉大学医学部1984级合影 武汉大学医学部1983级合影 武汉大学医学部1980级合影 武汉大学医学部1979级合影 武汉大学医学部1978级合影 武汉大学医学部1977级合影 武汉大学医学部1973级合影 武汉大学医学部1971级合影
2016年“向近敏教育基金” 奖、“... 国庆节期间多届海内外校友返校聚会 2015年“向近敏教育基金” 奖和“... 第二届“武汉大学医学部89级本科... 校友魏启赞捐款设立医学救助基金 夏冰教授的家人向武汉大学捐款设... 医学部接受校友及企业捐赠情况 82级校友捐款2万元注入朱裕璧医学... 武汉大学医学部部长致校友的感谢信

姓名:舒红兵

单位:武汉大学医学研究院

职称:教授、中国科学院院士、副校长、 院长

邮箱:shuh@whu.edu.cn

联系电话:027-68755692

研究方向:天然免疫与炎症反应机制











代表性论著:

1. Shu HB,Agranoff A, Nabel EG, Leung K, Neish AS, Collins , Nabel GJ* (1993).Differential regulation of VCAM-1 gene expression by specific NF-kB subunits in endothelial and epithelial cells.Mol Cell Biol13:6283-6289.

2. Shu HB, Li Z, Palacios MJ, Li Q, Joshi HC* (1995). A transient association of g-tubulin at the midbody is required for the completion of cytokinesis during the mammalian cell division.J Cell Sci108: 2955-2962.

3. Shu HB, Joshi HC* (1995). g-Tubulin can both neacleate microtubule assembly and self-assemble into tubular structures in mammalian cells.J Cell Biol130:1137-1147.

4. Hsu H,Shu HB,Pan MG, Goeddel DV* (1996). TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor-1 signal transduction pathways.Cell84:299-308.

5. Shu HB,Takeuchi M, Goeddel DV* (1996). The TNF receptor 2 signal transducers TRAF2 and c-IAP1 are components of the TNF receptor 1 signaling complex.P Natl Acad Sci USA93:13973-13978.

6.Shu HB,Halpins DR, Goeddel DV* (1997). Casperis a FADD and Caspase-related Inducer of Apoptosis.Immunity6:751-763.

7. Yeh WC, Pompa JL, McCurrach ME,Shu HB,Elia AJ, Shahinian A, Ng M, Wajegam A, Mithchell K, El-Deiry WS, Lowe SW, Goeddel DV M,ak TW* (1998). FADD: essential for embryonic development and signaling from some, but not all, inducers of apoptosis.Science279:1954-1958.

8.Shu HB*, Hu WH, Johnson H (1999). TALL-1 is a novel member of the TNF family that is downregulated by mitogens.J Leukocyte Biol65:680-683.

9. Hu WH, Johnson H,Shu HB*(1999). TRAIL signal NF-kB and JNK activation and apoptosis through distinct pathways. J Biol Chem274:30603-30610.

10. Hu WH, Johnson H,Shu HB* (2000). Activation of NF-kB by FADD, Casper and Caspase-8.J Biol Chem275:10838-10844.

11. Shu HB*,Johnson H (2000). BCMA is a receptor for the TNF family member TALL-1.P Natl Acad Sci USA97:9156-9161.

12. Chen D, Li X, Zhai Z,Shu HB*(2002).A novel zinc finger protein interacts with RIP and inhibits TNF- and IL-1-induced NF-kB activation.J Biol Chem.277:15985-15991.

13. Liu Y, Xu L, Opalka N, Kappler J,Shu HB, Zhang G* (2002). Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands.Cell108: 383-394.

14. Wu M, Xu L, Li X, Zhai Z ,Shu HB* (2002). AMID, an AIF homologous mitochondrion-associated protein, induces caspase-independent apoptosis. J Biol Chem277:25617-25623.

15. Xu L,Shu HB*(2002). TRAF3 is associated with BAFF-R and negatively regulates BAFF-R-mediated NF-kB activation and IL10 production.J Immunol169: 6883-6889.

16. Chen D, Xu LG, Chen L, Li L, Zhai Z, andShu HB*(2003). NIK is a component of the EGF/Heregulin receptor signaling complex.Oncogene22:4348-4355.

17. Wu M, Xu L, Zhai Z,Shu HB* (2003). SINK: a p65-interacting protein that negatively regulates NF-kB-dependent transcription. J Biol Chem278:27072-27079.

18. Bin L, Xu L,Shu HB*(2003). TIRP: a novel TIR domain-containing adapter protein involved in toll/interleukin-1 receptor signaling. J Biol Chem27:24526-24532.

19. Bin L, Nielson LD, Liu X, Mason RJ,Shu HB*(2003). Identification of UGRP1 and MARCO as a lung-specific ligand-receptor pair.J Immunol171:924-930.

20. Zhang J, Xu LG, Han KJ,Shu HB*(2004). Identification of a ZU5 and death domain containing inhibitor of NF-kB.J Biol Chem279:17819-17825.

21. Han KJ, Su X, Xu LG, Bin LH, Zhang J,Shu HB*(2004). Mechanisms of TRIF-induced ISRE and NF-kappa B activation and apoptosis pathways.J Biol Chem279:15652-15661.

22. Huang J, Teng L, Li L, Liu T, Li L, Chen D, Xu LG, Zhai Z,Shu HB*(2004). ZNF216 is an A20-like and IKKgamma -interacting inhibitor of NF-kappa B activation.J Biol Chem279:16847-16853.

23. Xu LG, Li LY,Shu HB* (2004). TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis.J Biol Chem279:17278-17282.

24. Wu M, Xu LG, Su T, Huang J, Zhai Z,Shu HB*(2004). AMID is a p53-inducible gene down-regulated in tumors.Oncogene23:6815-6819.

25. Li L, Bin LH, Li F, Liu Y, Chen D, Zhai Z,Shu HB*(2005). TRIP6 is a RIP2-associated common signaling component of multiple NF-kB activation pathways.J Cell Sci118:555-563.

26. Xu LG, Wang YY, Han KJ, Li LY, Zhai Z,Shu HB*(2005). VISA is an adapter protein required for virus-triggered signaling.Mol Cell19:727-740.

27. Huang J, Liu T, Chen D, Zhai Z,Shu HB*(2005). SIKE is an IKK-relative kinases-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways.EMBO J24:4018-4028.

28. Zha J, Han K, Xu LG, Zhou Q, Chen D, Zhai Z,Shu HB*(2006). The Ret finger protein inhibits signaling mediated by the noncanonical and canonical IKK family members.J Immunol176:1072-1080.

29. Tian Y, Zhang Y, Zhong B, Wang YY, Diao FC, Wang RP, Zhang M, Chen DY, Zhai ZH,Shu HB*(2007). RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation.J Biol Chem282:16776-16782.

30. Diao F, Li S, Tian Y, Zhang M, Xu LG, Zhang Y, Wang RP, Chen D, Zhai Z, Zhong B, Tien P,Shu HB*(2007). Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase.P Natl Acad Sci USA104:11706-11711.

31. Zhang M, Tian Y, Wang RP, Gao D, Zhang Y, Diao FC, Chen DY, Zhai ZH,Shu HB*(2008). Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3.Cell Res18:1096-1014.

32. Zhang B, Huang J, Li HL, Liu T, Wang YY, Waterman P, Mao AP, Xu LG, Zhai Z, Liu D, Marrack P,Shu HB*(2008). GIDE is a mitochondrial E3 ubiquitin ligase that induces apoptosis and slows growth.Cell Res18:900-910.

33. Zhong B, Yang Y, Li S, Wang YY, Li Y, Diao F, Lei C, He X, Zhang L, Tien P,Shu HB*(2008). The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation.Immunity29:538-550.

34. Zhong B, Zhang L, Lei Z, Li Y, Mao AP, Yang Y, Wang YY, Zhang XL,Shu HB*(2009). RNF5 negatively regulates virus-induced IRF3 activation via ubiquitination and degradation of MITA.Immunity30:397-407.

35. Li Y, Li C, Xue P, Zhong B, Mao AP, Ran Y, Chen H, Wang YY, Yang F,Shu HB*(2009). ISG56 is a negative feedback regulator of virus-triggered signaling and cellular antiviral response.P Natl Acad Sci USA106:7945-7950.

36. Wang YY, Liu LJ, Zhong B, Liu TT, Li Y, Yang Y, Ran Yong, Li S, Tien P,Shu HB*(2010). WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kB activation.P Natl Acad Sci USA107:815-820.

37. Li S, Zheng H, Mao AP, Zhong B, Li Y, Liu Y, Gao Y, Ran Y, Tien P,Shu, HB*(2010). Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6.J Biol Chem285:4291-4297.

38. Mao AP, Li S, Zhong B, Li Y, Yan J, Li Q, Teng C,Shu HB*(2010). Virus-triggered ubiquitination of TRAF3/6 by cIAP1/2 is essential for induction of interferon-beta (IFN-beta) and cellular antiviral response.J Biol Chem285:9470-9476.

39. Han KJ, Yang Y, Xu LG,Shu HB*(2010). Analysis of a TIR-less splice variant of TRIF reveals an unexpected mechanism of TLR3-mediated signaling.J Biol Chem285:12543-12550.

40. Chen R, Zhang L, Zhong B, Tan B, Liu Y,Shu HB*(2010).The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling.Cell Res20:802-811.

41. Zhong B, Zhang Y, Tan B, Liu TT, Wang YY,Shu HB* (2010).The E3 ubiquitin ligase RNF5 targets virus-induced signaling adaptor for ubiquitination and degradation.J Immunol184:6249-6255.

42. Lei CQ, Zhong B, Zhang Y, Zhang J,Shu HB*(2010). GSK3bregulates virus-triggered IRF3 activation and cellular antiviral response by promoting TBK1 activation.Immunity33:878-889.

43. Li Q, Yan J, Mao AP, Li C, Ran Y,Shu HB*, Wang YY*(2011). Tripartite motif 8 (TRIM8) modulates TNFa- and IL-1b-triggered NF-kB activation by targeting TAK1 for K63-linked polyubiquitination.P Natl Acad Sci USA108:19341-19346.

44. Ran Y, Liu TT, Zhou Q, Li S, Mao AP, Li Y, Liu LJ, Cheng JK,Shu HB*(2011).SENP2 negatively regulates cellular antiviral response by deSUMOylating IRF3 and conditioning it for ubiquitination and degradation.J Mol Cell Biol2:283-292.

45. Liu Y, Song R, Gao Y, Li Y, Wang S, Liu HY, Wang Y, Hu YH,Shu HB*(2012).Protein kinase C-δ negatively regulates T cell receptor-induced NF-kB activation by inhibiting the assembly of CARMA1 signalosome.J Biol Chem287:20081-20087.

46. He X, Li Y, Li C, Liu LJ, Zhang XD, Liu Y,Shu HB*(2012).USP2a negatively regulates IL-1β- and virus-induced NF-κB activation by deubiquitinating TRAF6.J Mol Cell Biol5:39-47.

47. Zhang J, Hu MM, Wang YY,Shu HB*(2012).TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination.J Biol Chem287:28646-28655.

48. Li Y, Chen R, Zhou Q, Xu Z, Li C, Wang S, Mao A, Zhang X, He W,Shu HB*(2012).LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection.P Natl Acad Sci USA109:11770-11775.

49. Wang YY*, Ran Y,Shu HB*(2012).Linear ubiquitination of NEMO brakes the antiviral response.Cell Host Microbe12:129-131.

50. Chen R, Li M, Zhang Y, Zhou Q,Shu HB*(2012).The E3 ubiquitin ligase MARCH8 negatively regulates IL-1β-induced NF-κB activation by targeting the IL1RAP coreceptor for ubiquitination and degradation.P Natl Acad Sci USA109:14128-14133.

51. Zheng H, Li Q, Chen R, Zhang J, Ran Y, He X, Li S,Shu HB*(2012).Dual-specificity phosphatase 14 (DUSP14) negatively regulates TNF-aand IL-1-induced NF-κB activation by dephosphorylating the protein kinase TAK1.J Biol Chem288:819-825.

52. Yang Y, Liao B, Wang S, Jin Y,Shu HB*, Wang YY*(2013). The E3 ubiquitin ligase WWP2 negatively regulates TLR3-mediated innate immune response by targeting TRIF for ubiquitination and degradation.PNAS110(13):5115-20.

53. Li C, Wei J, Li Y, He X, Zhou Q, Yan J, Zhang J, Liu Y, Liu Y,Shu HB*(2013).Transmembrane protein 214 (TMEM214) mediates endoplasmic reticulum stress-induced caspase-4 activation and apoptosis.J Biol Chem288

54. Lei CQ, Zhang Y, Xia T, Jiang LQ, Zhong B,Shu HB*(2013).FoxO1 Negatively Regulates Cellular Antiviral Response by Promoting Degradation of IRF3.J Biol Chem288:12596-12604.

55. Chen H, Li Y, Zhang J, Ran Y, Wei J, Yang Y,Shu HB*(2013).RAVER1 is a coactivator of MDA5-mediated cellular antiviral response.J Mol Cell Biol5:111-119.

56. Hu MM, Yang Q, Zhang J, Liu SM, Zhang Y, Lin H, Huang ZF, Wang YY, Zhang XD, Zhong B,Shu HB*(2013). TRIM38 inhibits TNFα- and IL-1β-triggered NF-κB activation by mediating lysosome-dependent degradation of TAB2/3.Proc. Natl. Acad. Sci. USA.111:1509-1514.

57. Yan J, Li Q, Mao AP, Hu MM,Shu HB*(2013). TRIM4 modulates type I interferon induction and cellular antiviral response by targeting RIG-I for K63-linked ubiquitination.J. Mol. Cell Biol.6:154-163.

58. Zhang Y, Lei CQ, Hu YH, Xia T, Li M, Zhong B,Shu HB*(2013). Kruppel-like Factor 6 Is a Co-activator of NF-κB That Mediates p65-dependent Transcription of Selected Downstream Genes.J. Biol. Chem289:12876-12885.

59. Qin Y, Zhou MT, Hu MM ,Hu YH, Zhang J, Guo L, Zhong B,Shu HB*(2014). RNF26 temporally regulates virus-triggered type I interferon induction by two distinct mechanisms.Plos Pathog10:e1004358.

60. Zhou Q, Lin H, Wang SY, Wang S, Ran Y, Liu Y, Ye W, Xiong XZ, Zhong B,Shu HB*,Wang YY*(2014). The ER-associated protein ZDHHC1 is a positive regulator of DNA virus-triggered, MITA/STING-dependent innate immune signaling.Cell Host Microbe16:450-61.

61. Ran Y,Shu HB, Wang YY*(2014). MITA/STING: A central and multifaceted mediator in innate immune response.Cytokine & Growth F R25: 631-639.

62. Shu HB*, Wang YY*(2014). Adding to the STING.Immunity41:871-3.

63. Hu YH, Zhang Y, Jiang LQ, Wang S, Lei CQ, Sun MS,Shu HB, Liu Y*(2015).WDFY1 mediates TLR3/4 signaling by recruiting TRIF.EMBO REP16: 447-455

64. Wei J, Lian H, Zhong B,Shu HB*(2015). Parafibromin Is a Component of IFN-γ-Triggered Signaling Pathways That Facilitates JAK1/2-Mediated Tyrosine Phosphorylation of STAT1.J Immunol195 : 2870-2878.

65. Hu MM, Xie XQ, Yang Q, Liao CY, Ye W, Lin H,Shu HB*(2015).TRIM38 Negatively Regulates TLR3/4-Mediated Innate Immune and Inflammatory Responses by Two Sequential and Distinct Mechanisms.J Immunol195: 4415-4425.