脑损伤保护和修复治疗方法的研究；2) 脑学习与记忆的细胞和分子机制。
研究神经递质受体在学习与记忆中的作用和分子机制，成果在Nature和Nature Neuroscience杂志上发表。探讨脑疾病发病和治疗机理，特别在脑损伤保护和神经干细胞再生等创新领域进行了一系列研究，在Nature Medicine, PNAS, Stem Cell, Aging Cell, Stroke, Annals of Surgery, Journal of Neuroscience 等杂志发表论文，应邀在Trends in Neuroscience杂志发表综述文章。
Wan Q, Man HY, Liu F, Braunton J, Niznik HB, Pang SF, Brown GM, Wang YT: Differential modulation of GABAA receptor function by MEL1a and MEL1b receptors. Nat Neurosci. 1999; 2(5): 401-403.
Wan Q, Xiong ZG, Man HY, Ackerley CA, Braunton J, Lu WY, Becker LE, MacDonald JF, Wang YT: Recruitment of functional GABAA receptors to postsynaptic domains by insulin. Nature. 1997; 388:686-690.
Liu F, Wan Q, Pristupa ZB, Yu XM, Wang YT, Niznik HB: Direct protein-protein coupling enables cross-talk between dopamine D5 and g-aminobutyric acid A receptors. Nature. 2000; 403:274-280.
Ning K, Li L, Liao M, Liu B, Mielke JG, Chen Y, Duan Y, El-Hayek YH, Wan Q: Circadian regulation of GABA(A) receptor function by CKIepsilon-CKIdelta in the rat suprachiasmatic nuclei. Nat Neurosci. 2004; 7(5):489-490.
Chang N, El-Hayek YH, Gomez E and Wan Q: Phosphatase PTEN in neuronal injury and brain disorders. Trends Neurosci. 2007; 30(11): 581-586.
Li LJ and Wan Q: rSac3, a new member of Sac domain phosphoinositide phosphatases family. Cell Res. 2007; 17:1-3.
Li L, El-Hayek YH, Liu BS, Chen Y, Gomez E, Wu XH, Ning K, Li LJ, Chang C, Zhang L, Wang ZG, Hu X, Wan Q: Direct-current Electrical Field Guides Neural Stem/progenitor Cell Migration. Stem Cells. 2008; 26(7): 1610-1836.
Chang N, Li L, Hu R, Shan Y, Liu B, Li L, Wang H, Feng H, Wang D, Cheung CC, Liao M and Wan Q: Differential regulation of NMDA receptor function by DJ-1 and PINK1. Aging Cell. 2010; 9:837–850.
Cheung CC, Yang C, Berger T, Zaugg K, Reilly P, Elia AJ, Wakeham A, You-Ten A, Chang N, Li LJ, Wan Q, and Mak TW: Identification of BERP (brain-expressed Ring finger protein) as a p53 target gene that modulates seizure susceptibility through interacting with GABA-A receptors. Proc Natl Acad Sci USA. 2010; 107(26):11883-8.
Liu B, Li L, Zhang Q, Chang N, Wang D, Shan Y, Li L, Wang H, Feng H, Zhang L, Brann DW and Wan Q: Preservation of GABAA receptor function by PTEN inhibition protects against neuronal death in ischemic stroke. Stroke. 2010; 41(5):1018-26.
11) Hu R, Sun H, Zhang Q, Chen J, Wu N, Meng H, Cui G, Hu S, Li F, Lin J, Wan Q, Feng H. G-protein coupled estrogen receptor 1 mediated estrogenic neuroprotection against spinal cord injury. Crit Care Med. 2012; 40(12):3230-7
Zheng M, Liao M, Cui T, Fan DS, and Wan Q: Regulation of nuclear TDP-43 by NR2A-containing NMDA receptor and phosphatase PTEN. J Cell Science. 2012; 125:1556-67
Hu R, Duan B, Wang D, Yu Y, Li W, Luo H, Lu P, Lin J, Zhu G, Wan Q and Feng H: Role of acid-sensing ion channel 1a in the secondary damage of traumatic spinal cord injury. Annals of Surgery. 2011;254:1–10
Li H, Chen HZ, Guo S, Li ZZ, Lu Y, Jiang DS, Zhang R, Lei H, Gao L, Zhang X, Zhang Y, Wang L, Zhu LH, Xiang M, Zhou Y, Wan Q, Dong H, and Liu DP. A Critical Role for Interferon Regulatory Factor 9 in Cerebral Ischemic Stroke. Journal of Neuronscience. 2014; 34(36):11897-912
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