医学部坐倚珞珈山,环绕东湖水,绿树成荫,花香流溢。学部源于1943年成立的湖北省省立医学院,现在是武汉大学六大学部之一。 学部含基础医学院、第一临床学院、第二临床学院、口腔医学院、药学院、健康学院、职业技术学院...

地址: 湖北省武汉市武昌区东湖路115号
电话:027-68759376
中国科学院院士: 邓子新舒红兵
国家级教学名师: 樊明文边专
国家杰出青年基金获得者: 邓子新舒红兵郭德银章晓联万芪李红良
千人计划入选: 霍文哲张发明、于学杰
青年千人计划入选: 陈实蒋卫钟波张好建、陈强、罗孟成、邓迎峰
百千万人才工程选者: 舒红兵、黄从新章晓联 
长江学者: 董晨舒红兵李红良
万人计划: 领军人才:舒红兵唐其柱李红良   青年拔尖人才: 刘天罡 、王连荣王培刚                
教育部新世纪优秀人才: 何小华 于红刚 李雁郑芳、胡锦跃、黄鹤
姓名:瞿旭东
单位:武汉大学药学院
职称:教授,博导、教育部新世纪优秀人才、国家优秀青年
邮箱:quxd@whu.edu.cn
联系电话:

研究方向:1、生物制造2、生物合成
代表性论著:

 

Independent work:

1、    Peng H, Wei E, Wang J, Zhang Y, Cheng L, Ma H, Deng Z, Qu X*. Deciphering piperidine formation in polyketide-derived indolizidines reveals a thioester reduction, transamination, and unusual imine reduction processACS Chem Biol. 2016, in press.

2、  Tan Z, Ma H, Li Q, Pu L, Cao Y, Qu X, Zhu C, Ying H. Biosynthesis of optically pure chiral alcohols by a substrate coupled and biphasic system with a short-chain dehydrogenase from Streptomyces griseus. Enzyme Microb Tech. 2016, 93, 191-199.

3、  Qi J, Wan D, Ma H, Liu Y, Gong R, Qu X, Sun Y, Deng Z, Chen W. Deciphering carbamoylpolyoxamic acid biosynthesis reveals unusual acetylation aycle associated with tandem-reduction and sequential-hydroxylation by single enzymes. Cell Chem Biol 2016, 23, 935-944.

4、  Wang Y, Wang J, Yu S, Wang F, Ma H, Yue C, Liu M, Deng Z, Huang Y*, Qu X*. Identifying the minimal enzymes for unusual carbon-sulfur bonds formation in the Thienodolin biosynthesis. ChemBioChem 2016, 17, 799-803.

5、  Chang C,# Huang R#(co-first author), Yan Y, Ma H, Dai Z, Zhang B, Liu W, Deng Z, Qu X*. Uncovering the formation and selection of benzylmalonyl-CoA from the biosynthesis of splenocin and enterocin reveals a versatile way to introduce amino acids into Polyketide carbon scaffolds. J Am Chem Soc 2015, 137, 4183-4190.

6、  Wang Y, Deng Z, Qu X*. Characterization of a SAM-dependent fluorinase from a latent biosynthetic pathway for fluoroacetate and 4-fluorothreonine formation in Nocardia brasiliensis. F1000Research 2014, 3: 61.

7、  Wu Q, Wu Z, Qu X*, Liu W*. Investigations into pyrroindomycin biosynthesis indicate a uniform paradigm for complex tetramate tetronate formation. J Am Chem Soc 2012, 134, 17342-17345.

8、  Qu X*, Pang B, Zhang Z, Chen M, Wu Z, Zhao Q, Zhang Q, Wang Y, Liu Y, Liu W*. Caerulomycins and collismycins share a common paradigm for 2, 2’-bipyridine biosynthesis via an unusual hybrid polyketide-peptide assembly logic. J Am Chem Soc 2012, 134, 9038-9041.

9、  Yan Y, Zhang L, Ito T, Qu X*, Asakawa Y, Awakawa T, Abe I, Liu W*. Biosynthetic pathway for high structural diversity of a common dilactone core in Antimycin production. Org Lett 2012, 14, 4142-4145.

Postdoc and graduate work

10、    Li J#, Qu X# (co-first author), He X, Duan L, Wu G, Bi D, Deng Z, Liu W, Ou H-Y. ThioFinder: A web-based tool for the identification of thiopeptide gene clusters in DNA sequences. PLOS ONE 2012, 7, e45878.

11、    Smanski M, Qu X, Liu W, Shen B.Chapter4-Biosynthesis of pharmaceutical natural products and their pathway engineering in Organic Chemistry-Breakthroughs and Perspectives.

12、    Qu X, Lei C, Liu W. Transcriptome mining of active biosynthetic pathways for natural product discovery. Angew Chem Int Ed 2011, 50, 9651-9654.

13、    Runguphan W#, Qu X# (co-first author), O’Connor S. Integrating carbon halogen bond formation into medicinal plant metabolism. Nature 2010, 468, 461-464.

14、    Qu X, Jiang N, Xu F, Shao L, Tang G, Wilkinson B, Liu W. Cloning, sequencing and characterization of the biosynthetic gene cluster of sanglifehrin A, a potent cyclophilin inhibitor. Mol BioSyst 2011, 7, 852-861.

15、    Shao L#, Qu X # (co-first author), Jia X, Zhao Q, Tian Z, Wang M, Tang G, Liu W. Cloning and characterization of a bacterial iterative type I polyketide synthase gene encoding the 6-methylsalicyclic acid synthase. Biochem Biophys Res Commun 2006, 345, 133-139.

16、    Jia X, Tian Z, Shao L, Qu X, Zhao Q, Tang J, Tang G, Liu W. Genetic characterization of the chlorothricin gene cluster as a model for spirotetronate antibiotic biosynthesis. Chem Biol 2006, 13, 575-585.