医学部坐倚珞珈山,环绕东湖水,绿树成荫,花香流溢。学部源于1943年成立的湖北省省立医学院,现在是武汉大学六大学部之一。 学部含基础医学院、第一临床学院、第二临床学院、口腔医学院、药学院、健康学院、职业技术学院...

地址: 湖北省武汉市武昌区东湖路115号
电话:027-68759376
中国科学院院士: 邓子新舒红兵
国家级教学名师: 樊明文边专
国家杰出青年基金获得者: 邓子新舒红兵郭德银章晓联万芪李红良
千人计划入选: 霍文哲张发明、于学杰
青年千人计划入选: 陈实蒋卫钟波张好建、陈强、罗孟成、邓迎峰
百千万人才工程选者: 舒红兵、黄从新章晓联 
长江学者: 董晨舒红兵李红良
万人计划: 领军人才:舒红兵唐其柱李红良   青年拔尖人才: 刘天罡 、王连荣王培刚                
教育部新世纪优秀人才: 何小华 于红刚 李雁郑芳、胡锦跃、黄鹤
姓名:邓子新
 单位:武汉大学药学院
 职称:院士、院长
 邮箱:zxdeng@whu.edu.cn
 联系电话:

 研究方向:微生物药物的合成途径、代谢工程及合成生物学,DNA硫修饰的遗传、生理及生化研究
代表性论著:

                           

                            1. Xu T, Yao F, Zhou X, Deng Z, You D (2010). A novel host-specific restriction system associated with DNA backbone S-modification in Salmonella. Nucleic Acids Research. Jul 12. [Epub ahead of print].

                      2. Shao Y, He X, Harrison EM, Tai C, Ou HY, Rajakumar K, Deng Z (2010). mGenomeSubtractor: a web-based tool for parallel in silico subtractive hybridization analysis of multiple bacterial genomes. Nucleic Acids Research. Sup:W194-200.

                      3. Zhao C, Coughlin JM, Ju J, Zhu D, Wendt-Pienkowski E, Zhou X, Wang Z, Shen B, Deng Z (2010). Oxazolomycin biosynthesis in Streptomyces albus JA3453 featuring an "acyltransferase-less" type I polyketide synthase that incorporates two distinct extender units. Journal of Biological Chemistry. 25;285(26):20097-108.

                      4. Chen W, Huang T, He X, Meng Q, You D, Bai L, Li J, Wu M, Li R, Xie Z, Zhou H, Zhou X, Tan H, Deng Z. (2009) Characterization of the polyoxin biosynthetic gene cluster from Streptomyces cacaoi and engineered production of polyoxin H. Journal of Biological Chemistry.17;284(16):10627-38.

                      5. Liu T, Cane DE, Deng Z. (2009) The enzymology of polyether biosynthesis. Methods in Enzymology, 459:187-214.

                      6. Xu H, Zhang Y, Yang J, Mahmud T, Bai L, Deng Z. (2009) Alternative Epimerization in C(7)N-Aminocyclitol Biosynthesis Is Catalyzed by ValD, A Large Protein of the Vicinal Oxygen Chelate Superfamily. Chemistry & Biology, 16(5):567-76.

                      7. Zhou Y, Li J, Zhu J, Chen S, Bai L, Zhou X, Wu H, Deng Z. (2008) Incomplete beta-Ketone Processing as a Mechanism for Polyene Structural Variation in the FR-008/Candicidin Complex. Chemistry & Biology,15(6):629-38.

                      8. Liu T, Lin X, Zhou X, Deng Z, Cane DE. (2008) Mechanism of thioesterase-catalyzed chain release in the biosynthesis of the polyether antibiotic nanchangmycin. Chemistry & Biology, 15(5):449-58.

                      9. Zhao P, Bai L, Ma J, Zeng Y, Li L, Zhang Y, Lu C, Dai H, Wu Z, Li Y, Wu X, Chen G, Hao X, Shen Y, Deng Z, Floss HG. (2008) Amide N-glycosylation by Asm25, an N-glycosyltransferase of ansamitocins. Chemistry & Biology. 15(8):863-74

                      10. L. Wang, S. Chen, T. Xu, K. Taghizadeh, J. S. Wishnok, X. Zhou, D. You, Z. Deng*, Peter C. Dedon* (2007), Phosphorothioation of DNA in bacteria by dnd gene clusters, Nature Chemical Biology, 3(11):709-710. (Featured by “News & Views” written by Fritz Eckstein, Nature Chem. Biol. 3(11): 689-690, and by ACS “C&E News” Written by Carmen Drahl).

                      11. X. He, H. Ou, Q. Yu, X. Zhou, J. Wu, J. Liang, W. Zhang, K. Rajakumar, and Z. Deng (2007). Analysis of a genomic island housing genes for DNA S-modification system in Streptomyces lividans 66 and its counterparts in other distantly related bacteria, Molecular Microbiology, 65(4):1034-48.

                      12. H. Ou, X. He, E. Harrison, B. Kulasekara, A. Thani, A. Kadioglu, S. Lory, J. Hinton, M. Barer, Z. Deng (2007): MobilomeFINDER: web-based tools for in silico and experimental discovery of bacterial genomic islands, Nucleic Acids Research. 5: W97-W104..

                      13. J. Liang, Z. Wang, X. He, J. Li, X. Zhou, and Z. Deng (2007). DNA modification by sulphur: analysis of the sequence recognition specificity surrounding the modification sites. Nucleic Acids Research. 35(9):2944-54.

                      14. T Liu, D You, C Valenzano, Y Sun, J Li, Q Yu, X Zhou, D. Cane, Z Deng (2006): Identification of NanE as the Thioesterase for Polyether Chain Release in Nanchangmycin Biosynthesis, Chemistry & Biology, 13(9):945-55.

                      15. L Bai, L Li, H Xu, K Minagawa, Y Yu, Y Zhang, X Zhou, H G. Floss, T Mahmud, and Z Deng (2006): Functional Analysis of the Validamycin Biosynthetic Gene Cluster and Engineered Production of Validoxylamine A, Chemistry & Biology, 13, 387-397. (Highlighted in Nature Biotechnology 24 (6): 665, 2006)。

                      16. T Liu, D You, C Valenzano, Y Sun, J Li, Q Yu, X Zhou, D. Cane, Z Deng (2006): Identification of NanE as the Thioesterase for Polyether Chain Release in Nanchangmycin Biosynthesis, Chemistry & Biology, 13(9):945-55.

                      17. L Bai, L Li, H Xu, K Minagawa, Y Yu, Y Zhang, X Zhou, H G. Floss, T Mahmud, and Z Deng (2006): Functional Analysis of the Validamycin Biosynthetic Gene Cluster and Engineered Production of Validoxylamine A, Chemistry & Biology, 13, 387-397. (Highlighted in Nature Biotechnology 24 (6): 665, 2006)。

                      18. Z. Deng and L. Bai (2006), Antibiotic biosynthetic pathways and pathway engineering--A growing research field in China, Natural Product Reports,23, 811 - 827.

                      19. X. Zhou, X. He, J. Liang., T. Xu, A. Li, T. Kieser, J. D. Helmann and Z. Deng (2005): A novel DNA modification by sulphur, Molecular Microbiology, 57(5): 1428-1438.

                      20. D. Zhu, X. He, X. Zhou, and Z. Deng (2005): Expression of the melC operon in several Streptomyces strains is positively regulated by AdpA, an AraC family transcriptional regulator involved in morphological development in Streptomyces coelicolor, Journal of Bacteriology, 187(9): 3180-3187.