医学部坐倚珞珈山,环绕东湖水,绿树成荫,花香流溢。学部源于1943年成立的湖北省省立医学院,现在是武汉大学六大学部之一。 学部含基础医学院、第一临床学院、第二临床学院、口腔医学院、药学院、健康学院、职业技术学院...

地址: 湖北省武汉市武昌区东湖路115号
电话:027-68759376
中国科学院院士: 邓子新舒红兵
国家级教学名师: 樊明文边专
国家杰出青年基金获得者: 邓子新舒红兵郭德银章晓联万芪李红良
千人计划入选: 霍文哲张发明、于学杰
青年千人计划入选: 陈实蒋卫钟波张好建、陈强、罗孟成、邓迎峰
百千万人才工程选者: 舒红兵、黄从新章晓联 
长江学者: 董晨舒红兵李红良
万人计划: 领军人才:舒红兵唐其柱李红良   青年拔尖人才: 刘天罡 、王连荣王培刚                
教育部新世纪优秀人才: 何小华 于红刚 李雁郑芳、胡锦跃、黄鹤
姓名:舒红兵
单位:武汉大学医学研究院
职称:教授、中国科学院院士、副校长、 院长
邮箱:shuh@whu.edu.cn
联系电话:027-68755692

研究方向:天然免疫与炎症反应机制
代表性论著:

 

1. Shu HB,Agranoff A, Nabel EG, Leung K, Neish AS, Collins , Nabel GJ* (1993).Differential regulation of VCAM-1 gene expression by specific NF-kB subunits in endothelial and epithelial cells. Mol Cell Biol13:6283-6289.

2. Shu HB, Li Z, Palacios MJ, Li Q, Joshi HC* (1995). A transient association of g-tubulin at the midbody is required for the completion of cytokinesis during the mammalian cell division. J Cell Sci108: 2955-2962.

3. Shu HB, Joshi HC* (1995). g-Tubulin can both neacleate microtubule assembly and self-assemble into tubular structures in mammalian cells. J Cell Biol130:1137-1147.

4. Hsu H, Shu HB,Pan MG, Goeddel DV* (1996). TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor-1 signal transduction pathways. Cell84:299-308.

5. Shu HB,Takeuchi M, Goeddel DV* (1996). The TNF receptor 2 signal transducers TRAF2 and c-IAP1 are components of the TNF receptor 1 signaling complex. P Natl Acad Sci USA93:13973-13978.

6. Shu HB,Halpins DR, Goeddel DV* (1997). Casperis a FADD and Caspase-related Inducer of Apoptosis.Immunity6:751-763.

7. Yeh WC, Pompa JL, McCurrach ME, Shu HB,Elia AJ, Shahinian A, Ng M, Wajegam A, Mithchell K, El-Deiry WS, Lowe SW, Goeddel DV M,ak TW* (1998). FADD: essential for embryonic development and signaling from some, but not all, inducers of apoptosis.Science279:1954-1958.

8. Shu HB*, Hu WH, Johnson H (1999). TALL-1 is a novel member of the TNF family that is downregulated by mitogens. J Leukocyte Biol65:680-683.

9. Hu WH, Johnson H,Shu HB*(1999). TRAIL signal NF-kB and JNK activation and apoptosis through distinct pathways. J Biol Chem274:30603-30610.

10. Hu WH, Johnson H, Shu HB* (2000). Activation of NF-kB by FADD, Casper and Caspase-8.J Biol Chem275:10838-10844.

11. Shu HB*,Johnson H (2000). BCMA is a receptor for the TNF family member TALL-1.P Natl Acad Sci USA97:9156-9161.

12. Chen D, Li X, Zhai Z, Shu HB*(2002).A novel zinc finger protein interacts with RIP and inhibits TNF- and IL-1-induced NF-kB activation. J Biol Chem.277:15985-15991.

13. Liu Y, Xu L, Opalka N, Kappler J, Shu HB, Zhang G* (2002). Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands.Cell108: 383-394.

14. Wu M, Xu L, Li X, Zhai Z ,Shu HB* (2002). AMID, an AIF homologous mitochondrion-associated protein, induces caspase-independent apoptosis. J Biol Chem277:25617-25623.

15. Xu L, Shu HB*(2002). TRAF3 is associated with BAFF-R and negatively regulates BAFF-R-mediated NF-kB activation and IL10 production. J Immunol169: 6883-6889.

16. Chen D, Xu LG, Chen L, Li L, Zhai Z, and Shu HB*(2003). NIK is a component of the EGF/Heregulin receptor signaling complex.Oncogene22:4348-4355.

17. Wu M, Xu L, Zhai Z, Shu HB* (2003). SINK: a p65-interacting protein that negatively regulates NF-kB-dependent transcription. J Biol Chem278:27072-27079.

18. Bin L, Xu L, Shu HB*(2003). TIRP: a novel TIR domain-containing adapter protein involved in toll/interleukin-1 receptor signaling. J Biol Chem27:24526-24532.

19. Bin L, Nielson LD, Liu X, Mason RJ, Shu HB*(2003). Identification of UGRP1 and MARCO as a lung-specific ligand-receptor pair. J Immunol171:924-930.

20. Zhang J, Xu LG, Han KJ, Shu HB*(2004). Identification of a ZU5 and death domain containing inhibitor of NF-kB. J Biol Chem279:17819-17825.

21. Han KJ, Su X, Xu LG, Bin LH, Zhang J, Shu HB*(2004). Mechanisms of TRIF-induced ISRE and NF-kappa B activation and apoptosis pathways. J Biol Chem279:15652-15661.

22. Huang J, Teng L, Li L, Liu T, Li L, Chen D, Xu LG, Zhai Z,Shu HB*(2004). ZNF216 is an A20-like and IKKgamma -interacting inhibitor of NF-kappa B activation. J Biol Chem279:16847-16853.

23. Xu LG, Li LY, Shu HB* (2004). TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis. J Biol Chem279:17278-17282.

24. Wu M, Xu LG, Su T, Huang J, Zhai Z,Shu HB*(2004). AMID is a p53-inducible gene down-regulated in tumors.Oncogene23:6815-6819.

25. Li L, Bin LH, Li F, Liu Y, Chen D, Zhai Z, Shu HB*(2005). TRIP6 is a RIP2-associated common signaling component of multiple NF-kB activation pathways. J Cell Sci118:555-563.

26. Xu LG, Wang YY, Han KJ, Li LY, Zhai Z, Shu HB*(2005). VISA is an adapter protein required for virus-triggered signaling. Mol Cell19:727-740.

27. Huang J, Liu T, Chen D, Zhai Z,Shu HB*(2005). SIKE is an IKK-relative kinases-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways. EMBO J24:4018-4028.

28. Zha J, Han K, Xu LG, Zhou Q, Chen D, Zhai Z, Shu HB*(2006). The Ret finger protein inhibits signaling mediated by the noncanonical and canonical IKK family members. J Immunol176:1072-1080.

29. Tian Y, Zhang Y, Zhong B, Wang YY, Diao FC, Wang RP, Zhang M, Chen DY, Zhai ZH, Shu HB*(2007). RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation. J Biol Chem282:16776-16782.

30. Diao F, Li S, Tian Y, Zhang M, Xu LG, Zhang Y, Wang RP, Chen D, Zhai Z, Zhong B, Tien P, Shu HB*(2007). Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase. P Natl Acad Sci USA104:11706-11711.

31. Zhang M, Tian Y, Wang RP, Gao D, Zhang Y, Diao FC, Chen DY, Zhai ZH, Shu HB*(2008). Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3.Cell Res18:1096-1014.

32. Zhang B, Huang J, Li HL, Liu T, Wang YY, Waterman P, Mao AP, Xu LG, Zhai Z, Liu D, Marrack P, Shu HB*(2008). GIDE is a mitochondrial E3 ubiquitin ligase that induces apoptosis and slows growth. Cell Res18:900-910.

33. Zhong B, Yang Y, Li S, Wang YY, Li Y, Diao F, Lei C, He X, Zhang L, Tien P, Shu HB*(2008). The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation.Immunity29:538-550.

34. Zhong B, Zhang L, Lei Z, Li Y, Mao AP, Yang Y, Wang YY, Zhang XL, Shu HB*(2009). RNF5 negatively regulates virus-induced IRF3 activation via ubiquitination and degradation of MITA.Immunity30:397-407.

35. Li Y, Li C, Xue P, Zhong B, Mao AP, Ran Y, Chen H, Wang YY, Yang F, Shu HB*(2009). ISG56 is a negative feedback regulator of virus-triggered signaling and cellular antiviral response. P Natl Acad Sci USA106:7945-7950.

36. Wang YY, Liu LJ, Zhong B, Liu TT, Li Y, Yang Y, Ran Yong, Li S, Tien P, Shu HB*(2010). WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kB activation. P Natl Acad Sci USA107:815-820.

37. Li S, Zheng H, Mao AP, Zhong B, Li Y, Liu Y, Gao Y, Ran Y, Tien P,Shu, HB*(2010). Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6.J Biol Chem285:4291-4297.

38. Mao AP, Li S, Zhong B, Li Y, Yan J, Li Q, Teng C, Shu HB*(2010). Virus-triggered ubiquitination of TRAF3/6 by cIAP1/2 is essential for induction of interferon-beta (IFN-beta) and cellular antiviral response. J Biol Chem285:9470-9476.

39. Han KJ, Yang Y, Xu LG,Shu HB*(2010). Analysis of a TIR-less splice variant of TRIF reveals an unexpected mechanism of TLR3-mediated signaling. J Biol Chem285:12543-12550.

40. Chen R, Zhang L, Zhong B, Tan B, Liu Y,Shu HB*(2010).The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling.Cell Res20:802-811.

41. Zhong B, Zhang Y, Tan B, Liu TT, Wang YY, Shu HB* (2010).The E3 ubiquitin ligase RNF5 targets virus-induced signaling adaptor for ubiquitination and degradation.J Immunol184:6249-6255.

42. Lei CQ, Zhong B, Zhang Y, Zhang J, Shu HB*(2010). GSK3bregulates virus-triggered IRF3 activation and cellular antiviral response by promoting TBK1 activation.Immunity33:878-889.

43. Li Q, Yan J, Mao AP, Li C, Ran Y, Shu HB*, Wang YY*(2011). Tripartite motif 8 (TRIM8) modulates TNFa- and IL-1b-triggered NF-kB activation by targeting TAK1 for K63-linked polyubiquitination.P Natl Acad Sci USA108:19341-19346.

44. Ran Y, Liu TT, Zhou Q, Li S, Mao AP, Li Y, Liu LJ, Cheng JK, Shu HB*(2011).SENP2 negatively regulates cellular antiviral response by deSUMOylating IRF3 and conditioning it for ubiquitination and degradation.J Mol Cell Biol2:283-292.

45. Liu Y, Song R, Gao Y, Li Y, Wang S, Liu HY, Wang Y, Hu YH, Shu HB*(2012).Protein kinase C-δ negatively regulates T cell receptor-induced NF-kB activation by inhibiting the assembly of CARMA1 signalosome.J Biol Chem287:20081-20087.

46. He X, Li Y, Li C, Liu LJ, Zhang XD, Liu Y, Shu HB*(2012).USP2a negatively regulates IL-1β- and virus-induced NF-κB activation by deubiquitinating TRAF6.J Mol Cell Biol5:39-47.

47. Zhang J, Hu MM, Wang YY, Shu HB*(2012).TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination.J Biol Chem287:28646-28655.

48. Li Y, Chen R, Zhou Q, Xu Z, Li C, Wang S, Mao A, Zhang X, He W, Shu HB*(2012).LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection.P Natl Acad Sci USA109:11770-11775.

49. Wang YY*, Ran Y, Shu HB*(2012).Linear ubiquitination of NEMO brakes the antiviral response.Cell Host Microbe12:129-131.

50. Chen R, Li M, Zhang Y, Zhou Q,Shu HB*(2012).The E3 ubiquitin ligase MARCH8 negatively regulates IL-1β-induced NF-κB activation by targeting the IL1RAP coreceptor for ubiquitination and degradation.P Natl Acad Sci USA109:14128-14133.

51. Zheng H, Li Q, Chen R, Zhang J, Ran Y, He X, Li S, Shu HB*(2012).Dual-specificity phosphatase 14 (DUSP14) negatively regulates TNF-aand IL-1-induced NF-κB activation by dephosphorylating the protein kinase TAK1.J Biol Chem288:819-825.

52. Yang Y, Liao B, Wang S, Jin Y, Shu HB*, Wang YY*(2013). The E3 ubiquitin ligase WWP2 negatively regulates TLR3-mediated innate immune response by targeting TRIF for ubiquitination and degradation.PNAS110(13):5115-20.

53. Li C, Wei J, Li Y, He X, Zhou Q, Yan J, Zhang J, Liu Y, Liu Y, Shu HB*(2013). Transmembrane protein 214 (TMEM214) mediates endoplasmic reticulum stress-induced caspase-4 activation and apoptosis.J Biol Chem288

54. Lei CQ, Zhang Y, Xia T, Jiang LQ, Zhong B,Shu HB*(2013).FoxO1 Negatively Regulates Cellular Antiviral Response by Promoting Degradation of IRF3.J Biol Chem288:12596-12604.

55. Chen H, Li Y, Zhang J, Ran Y, Wei J, Yang Y,Shu HB*(2013).RAVER1 is a coactivator of MDA5-mediated cellular antiviral response.J Mol Cell Biol5:111-119.

56. Hu MM, Yang Q, Zhang J, Liu SM, Zhang Y, Lin H, Huang ZF, Wang YY, Zhang XD, Zhong B,Shu HB*(2013). TRIM38 inhibits TNFα- and IL-1β-triggered NF-κB activation by mediating lysosome-dependent degradation of TAB2/3.Proc. Natl. Acad. Sci. USA.111:1509-1514.

57. Yan J, Li Q, Mao AP, Hu MM, Shu HB*(2013). TRIM4 modulates type I interferon induction and cellular antiviral response by targeting RIG-I for K63-linked ubiquitination.J. Mol. Cell Biol.6:154-163.

58. Zhang Y, Lei CQ, Hu YH, Xia T, Li M, Zhong B,Shu HB*(2013). Kruppel-like Factor 6 Is a Co-activator of NF-κB That Mediates p65-dependent Transcription of Selected Downstream Genes. J. Biol. Chem289:12876-12885.

59. Qin Y, Zhou MT, Hu MM ,Hu YH, Zhang J, Guo L, Zhong B, Shu HB*(2014). RNF26 temporally regulates virus-triggered type I interferon induction by two distinct mechanisms. Plos Pathog10:e1004358.

60. Zhou Q, Lin H, Wang SY, Wang S, Ran Y, Liu Y, Ye W, Xiong XZ, Zhong B,Shu HB*, Wang YY*(2014). The ER-associated protein ZDHHC1 is a positive regulator of DNA virus-triggered, MITA/STING-dependent innate immune signaling. Cell Host Microbe16:450-61.

61. Ran Y, Shu HB, Wang YY*(2014). MITA/STING: A central and multifaceted mediator in innate immune response. Cytokine & Growth F R25: 631-639.

62. Shu HB*, Wang YY*(2014). Adding to the STING. Immunity41:871-3.

63. Hu YH, Zhang Y, Jiang LQ, Wang S, Lei CQ, Sun MS, Shu HB, Liu Y*(2015).WDFY1 mediates TLR3/4 signaling by recruiting TRIF. EMBO REP16: 447-455

64. Wei J, Lian H, Zhong B,Shu HB*(2015). Parafibromin Is a Component of IFN-γ-Triggered Signaling Pathways That Facilitates JAK1/2-Mediated Tyrosine Phosphorylation of STAT1. J Immunol195 : 2870-2878.

65. Hu MM, Xie XQ, Yang Q, Liao CY, Ye W, Lin H, Shu HB*(2015).TRIM38 Negatively Regulates TLR3/4-Mediated Innate Immune and Inflammatory Responses by Two Sequential and Distinct Mechanisms.J Immunol195: 4415-4425.